Last updated: Tue, Aug 13, 2024
Neuropathies caused by the cancer or by the cancer treatment follow the general pattern described in the section on neuropathic pain (see Neuropathies).
Cancers are slightly more acidic than normal tissue. Cancers that have spread to bone create a particularly acidic environment because the osteoclasts (bone-destroying cells) that eventually weaken the bone work by creating a highly acidic zone. The highly acid environment sensitizes some of the nociceptors in the bone, leading to the pain of bone cancer.