Pain Associated with Cancer

Last updated: Wed, Jun 28, 2017

Pain can result from the cancer itself and from various treatments for cancer. Cells of the tumor and cells associated with the tumor may release pain-inducing substances including acid (hydrogen ions or protons), bradykinin, endothelins, prostaglandins, proteases, and tyrosine kinase activators. Some of these substances induce sprouting on existing somatic and sympathetic nerve fibers, leading to neuropathic pains. The growth of tumors can physically impinge on nerves, leading to another form of neuropathic pain. Pain from tumors is often described as dull, and increases as the tumor grows. Radiation therapy and some chemotherapies can be toxic to nerves, leading to neuropathies caused by the treatment. A number of ancillary treatment procedures are painful without causing neuropathy.

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Epidemiology of Pain Associated with Cancer (Last updated: Wed, Jun 28, 2017)

Causes of Pain Associated with Cancer (Last updated: Tue, Aug 13, 2024)

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Other Pain Conditions (Last updated: Thu, Nov 17, 2022)