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Chronic pain is associated with changes in nervous system morphology
Greater decreases in gray matter are observed in patients with longer pain duration (see Fig. 7-10), thus suggesting that alterations in gray matter are a consequence of pain or (prolonged) nociceptive input. This concept is further supported by two additional lines of evidence. First, a longitudinal study in a rat mo....
McMahon, S. B., Koltzenberg, M., Tracy, I., and Turk, D. C., "Wall and Melzack's Textbook of Pain", Elsevier Saunders, 2013, 125
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